Ram then accompanies the trucks through Virgillo country, enabling the trucks to pass through. Morales's chauffeur Angel overhears Ram talking to Tommy, and finds out his identity. Ram successfully steals the trucks,as well as blowing up the Virgillos' ship. Afterwards, Ram is enlisted the task of recovering three stolen trucks that will be used for Morales's trafficking deal. Morales sends Ram to steal the Virgillo's prized car, only to blow it up. Marco refers Ram to Cesar Morales, a local gang boss who had bragged of knowing Ernesto's murderer. Ram saves Marco from a group of Virgillos who want to kill him because he was winning too much. Ramiro is a criminal and was sent to prison for many reasons. Tommy calls his younger brother Ramiro to take the job.

Tommy destroys a Virgillo gang convoy and their gas station but is seriously wounded by a grenade explosion. Tommy a high-ranking DEA agent and the son of Ernesto, goes to Mexico and finds Marco, who is his primary contact with Morales Cartel. Colonel (Commander of Tommy) Trust believes it's a drug overdose. After the attack, Ernesto is thrown from the plane and is killed. In 1989, Ernesto Cruz, a deep-cover DEA agent, and a DEA army, attack the military in a jungle to take some information on Papa Muerte. The Furies will try to stop you during the story of Total Overdose. Between story missions the player can do optional challenge missions as he or she wishes, exploring Los Toros and gathering bonuses to rack up a high score. The player will be tasked with infiltrating and taking down the biggest drug cartel in Mexico and battling it out with dope dealers, banditos, corrupt Federales and Mexican Army, loco luchadores, guerillas, and other assorted bad guys. He has been sent into the Mexican border city of Los Toros and its surroundings by his twin brother Tommy, who wants him to find out who killed their father Ernesto Cruz. The player assumes the unexisting role of Ramiro 'Ram' Cruz criminal turned DEA Agent.

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